Formulation and Characterization of Controlled Release Flurbiprofen Microsponges Loaded in Gels

The formulation of flurbiprofen loaded microspheres using hydroxypropylmethycellulose and ethylcellulose.

OBJECTIVES The aim of the present work was to formulate flurbiprofen (FLB) loaded microspheres of hydroxypropylmethycellulose and ethylcellulose polymers to study the effect of different proportions of the polymer mixture on the release behavior of the drug. MATERIAL AND METHODS A series of microspheres were prepared using tween-80 as a surfactant. The prepared microspheres were evaluated for...

Preparation and Characterization of Thermoresponsive In-situ Forming Poloxamer Hydrogel for Controlled Release of Nile red-loaded Solid Lipid Nanoparticles

Preparation and characterization of thermoresponsive in-situ forming poloxamer hydrogel for controlled release of Nile red-loaded solid lipid nanoparticles. Nanoparticles (NPs) are cleared rapidly from systemic circulation and do not provide sustained action in most cases. To solve this problem, this investigation introduces an erodible in-situ forming gel system as potential vehicles for prolo...

The Effect of Formulation Type on the Release of Benzoyl Peroxide from Microsponges

      Benzoyl peroxide (BPO) is a first-line topical treatment in acne vulgaris, and it is superior to antibiotics, because the bacteria do not develop resistance to it. Skin irritation is a common side effect, and it has been shown that controlled release of BPO from a delivery system to the skin could reduce the side effects while reducing percutaneous absorption. Therefore, the purpose of t...

formulation and characterization of ionotropic cross-linked chitosan microspheres for controlled release of ascorbic acid

Development and characterization of eudragit RS 100 loaded microsponges and its colonic delivery using natural polysaccharides.

In the present work, paracetamol loaded eudragit based microsponges were prepared using quasi-emulsion solvent diffusion method. The compatibility of the drug with various formulation components was established. Process parameters were analyzed in order to optimize the formulation. Shape and surface morphology of the microsponges were examined using scanning electron microscopy. The formulation...